Strong
Fibre is the finding that holds up
Dose-dependent reductions in all-cause and cause-specific mortality across meta-analyses. Most Europeans eat about half the recommended intake.
O eixo intestino-cérebro é real. Quase tudo vendido com base nisso está anos à frente das evidências humanas — com uma grande exceção.
Fibre has large, consistent, dose-dependent effects on hard outcomes and almost nobody eats enough of it. Probiotics have small and inconsistent effects on mood. Microbiome testing services have essentially nothing. The gap between those three statements is the whole story of this field.
Strong
Dose-dependent reductions in all-cause and cause-specific mortality across meta-analyses. Most Europeans eat about half the recommended intake.
Weak
Meta-analyses find small effects on depression and anxiety symptoms, in trials with real quality problems.
Mechanism
Vagal signalling, microbial metabolites and immune pathways — most of it characterised in rodents.
Caution
There is no validated healthy reference microbiome, and results vary by sampling and sequencing method.
Diets, drugs, behaviour and maintenance — ranked by the strength of the evidence behind them.
Coeliac disease news, guidelines and research — plus the practical business of eating.
Health, science and self-improvement books fact-checked against the literature they cite.
Crohn's disease and ulcerative colitis — guidelines, biologics, diet and the trigger-food question.
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